Globidens tooth with root nicely displayed on matrix.

Globidens got its name from the fact that its teeth were spherical, unlike those of other mosasaurs. The majority of mosasaurs have teeth that they had developed to grasp soft, slippery prey like fish and squid; some later species changed their teeth to also rip flesh. 

No other mosasaur was as skilled at destroying armored prey as Globidens, despite the fact that several others could break ammonite shells. The semispherical, rounded-pointed teeth of globidens were ideal for crushing strong, armored prey, including tiny turtles, ammonites, nautili, and bivalves.