FRAT IgG Test

Folate Receptor Autoantibody Test (FRAT)

The FRAT IgG Test (Folate Receptor Autoantibody Test) is a specialized blood test that helps identify whether folate receptor autoantibodies are interfering with the transport of folate (Vitamin B9) into the brain. Folate plays a critical role in brain development, speech, cognition, attention, behavior, and neurological function.

Research has shown that a significant percentage of children on the autism spectrum may have folate receptor autoantibodies, which can affect how folate reaches the brain even when blood folate levels appear normal.

Why is the FRAT Test Important in Autism?

Many children on the spectrum may experience challenges related to:

• Speech and language delay
• Attention and focus difficulties
• Behavioral dysregulation
• Sensory concerns
• Developmental delays
• Cognitive and learning challenges

In some children, impaired folate transport to the brain may be one of the contributing biological factors. The FRAT IgG Test helps identify this possibility and supports deeper clinical understanding.