CD1B rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8672-50, ES8672-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008],

Alternate Name: T-cell surface glycoprotein CD1b (CD antigen CD1b)

Source: Rabbit

Applications: IHC; IF; ELISA

Dilution: IHC-p 1:50-200, ELISA 1:10000-20000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthetic peptide from human protein at AA range: 60-100

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 910

Human SWISS Prot NO: P29016

Subcellular Location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.

Research Use Only