CGP 35348 is a selective antagonist of γ-aminobutyric acidB (GABAB) receptor with IC50 value of 34 μM . The GABAB receptor is a metabotropic transmembrane receptors for GABA that is linked via G-protein to potassium channel. It stimulates the opening of K+ channel and hyperpolarize the neuron. CGP 35348 is a selective GABAB receptor antagonist that can penetrate the blood-brain barrier. In rat cortex slices, CGP 35348 inhibited the potentiating effect of L-baclofen on adenylate cyclase stimulated by noradrenaline. In the hippocampal slice, CGP 35348 (10, 30, 100 μM) inhibited membrane hyperpolarization induced by L-baclofen (10 μM) and the inhibitory postsynaptic potential . In the spinal cord of the rat, CGP 35348 (3-30 μg) inhibited L-baclofen-induced antinociception in a dose-dependent way . In the rat, CGP 35348 induced pain-like response to mechanical stimulation in a dose-dependent way and reduced the paw withdrawal threshold to pressure . In rats, CGP 35348(500 mg/kg) significantly reduced food consumption by the blockade of central GABAB receptors .

Product information

CAS Number: 123690-79-9

Molecular Weight: 225.22

Formula: C8H20NO4P

Chemical Name: (3-aminopropyl)(diethoxymethyl)phosphinic acid

Smiles: CCOC(OCC)[P@](O)(=O)CCCN

InChiKey: QIIVUOWTHWIXFO-UHFFFAOYSA-N

InChi: InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.