AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1.

Product information

CAS Number: 1295514-91-8

Molecular Weight: 505.58

Formula: C25H34F3N7O

Chemical Name: (5R)-5-methyl-4-(4-{1-[2-(pyrrolidin-1-yl)ethyl]-4-(3,3,3-trifluoropropyl)-1H-imidazol-2-yl}piperidin-1-yl)-5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-7-one

Smiles: C[C@@H]1CC(=O)NC2=NC=NC(=C21)N1CCC(CC1)C1=NC(CCC(F)(F)F)=CN1CCN1CCCC1

InChiKey: QRULDXBXPXGMQS-QGZVFWFLSA-N

InChi: InChI=1S/C25H34F3N7O/c1-17-14-20(36)32-22-21(17)24(30-16-29-22)34-10-5-18(6-11-34)23-31-19(4-7-25(26,27)28)15-35(23)13-12-33-8-2-3-9-33/h15-18H,2-14H2,1H3,(H,29,30,32,36)/t17-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

AKT-IN-2 (Compound 8) also inhibits P70S6K, PKA, PKCβ2, RSK1, and pGSK3β with IC50s of 0.399, 0.084, 3.98, 0.568, and 0.092 μM, respectively.

Products are for research use only. Not for human use.