N-Azido-PEG4-N-Boc-N-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 2093152-85-1

Molecular Weight: 622.75

Formula: C28H54N4O11

Chemical Name: tert-butyl 3-(2-{2-[2-(19-azido-2,2-dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-5-yl)ethoxy]ethoxy}ethoxy)propanoate

Smiles: CC(C)(C)OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCOCCN=[N+]=[N-])C(=O)OC(C)(C)C

InChiKey: NWHTZGJNDFXFNW-UHFFFAOYSA-N

InChi: InChI=1S/C28H54N4O11/c1-27(2,3)42-25(33)7-11-35-15-19-39-21-17-37-13-9-32(26(34)43-28(4,5)6)10-14-38-18-22-41-24-23-40-20-16-36-12-8-30-31-29/h7-24H2,1-6H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.