ALK (phospho-Tyr1078) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES18394-50, ES18394-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome

Alternate Name: ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)

Source: Rabbit

Applications: WB

Dilution: WB 1:1000-2000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized phosho peptide around human ALK (Tyr1078)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 150-240kD

Human Gene ID: 238

Human SWISS Prot NO: Q9UM73

Subcellular Location: Cell membrane; Single-pass type I membrane protein. Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.

Research Use Only