c-Cbl (phospho-Tyr731) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES17789-50, ES17789-100

Citations, Manuals and MSDS Available upon request.

Background: Cbl proto-oncogene (CBL) Homo sapiens This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016],

Alternate Name: E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (Signal transduction protein CBL)

Source: Rabbit

Applications: WB

Dilution: WB 1:1000-2000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized phosho peptide around human c-Cbl (Tyr731)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 100kD

Human Gene ID: 867

Human SWISS Prot NO: P22681

Subcellular Location: Cytoplasm. Cell membrane. Cell projection, cilium. Golgi apparatus. Colocalizes with FGFR2 in lipid rafts at the cell membrane.

Research Use Only