Phospho-IKK alpha (Thr23) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16296-50, BZ16296-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: O15111

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-P

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100

Background: Plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 85 kDa; Observed MW: 85 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-IKK alpha in 293 lysates using Phospho-IKK alpha antibody., Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma tissue using IKK a antibody. High-pressure and temperature Sodium Citrate pH 6. 0 was used for antigen retrieval. Sample with blocking peptide on the right.

Alternative Name: CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B

Immunogen: Synthetic peptide of human CHUK

Conjugate: Unconjugated

Modification: Phosphorylated