NPRL2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3816-50, ES3816-100

Citations, Manuals and MSDS Available upon request.

Background: function:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs., similarity:Belongs to the NPR2 family., subunit:Interacts with PDPK1., tissue specificity:Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.,

Alternate Name: NPRL2; TUSC4; Nitrogen permease regulator 2-like protein; NPR2-like protein; Gene 21 protein; G21 protein; Tumor suppressor candidate 4

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from the C-terminal region of human NPRL2.

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 43kD

Human Gene ID: 10641

Human SWISS Prot NO: Q8WTW4

Subcellular Location: Lysosome membrane. Localization to lysosomes is amino acid-independent.

Research Use Only