53BP1 (phospho-Ser1778) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES18530-50, ES18530-100

Citations, Manuals and MSDS Available upon request.

Alternate Name: Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)

Source: Rabbit

Applications: WB

Dilution: WB 1:1000-2000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized phosho peptide around human 53BP1 (Ser1778)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 213kD

Human Gene ID: 7158

Human SWISS Prot NO: Q12888

Subcellular Location: Nucleus. Chromosome. Chromosome, centromere, kinetochore. Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity).

Research Use Only