Phospho-TrkB (Tyr705) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11898-50, MB11898-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q16620

Host: Rabbit

Reactivity: Human, Rat

Applications: WB

All Applications: WB: 1/500-1/1000

Background: The family of Trk receptor tyrosine kinases consists of TrkA, TrkB and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Phospho-TrkB in Hela, A549, C6Lysates using Phospho-TrkB antibody.

Bioworld Molecular Weight: Calculated MW: 92 kDa; Observed MW: 140,90 kDa

Specificity: IgG

Alternative Name: NTRK2; TRKB; BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Tyr705 of human TrkB

Conjugate: Unconjugated

Modification: Phosphorylated