BM635 hydrochloride is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 hydrochloride has an MIC50 of 0.08 μM against M.tuberculosis H37Rv. BM635 hydrochloride doubles the in vivo exposure with respect to the free base BM635.

Product information

Molecular Weight: 428.97

Formula: C25H30ClFN2O

Chemical Name: 4-[[1-(4-fluorophenyl)-2-methyl-5-(4-propan-2-ylphenyl)pyrrol-3-yl]methyl]morpholine;hydrochloride

Smiles: Cl.CC1=C(CN2CCOCC2)C=C(C2C=CC(=CC=2)C(C)C)N1C1C=CC(F)=CC=1

InChiKey: JUVYBPYTCHPFBF-UHFFFAOYSA-N

InChi: InChI=1S/C25H29FN2O.ClH/c1-18(2)20-4-6-21(7-5-20)25-16-22(17-27-12-14-29-15-13-27)19(3)28(25)24-10-8-23(26)9-11-24;/h4-11,16,18H,12-15,17H2,1-3H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

BM635 hydrochloride (oral administration; 50 mg/Kg) results in gradual elevations in blood up to a Cmax of 579.1 ng/ml with Tmax of 3 hour. It doubles the in vivo exposure with respect to the free base BM635 in C57BL/6J mice.

Products are for research use only. Not for human use.