CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia.

Product information

CAS Number: 780763-95-3

Molecular Weight: 474.94

Formula: C26H23ClN4O3

Chemical Name: 2-[4-chloro-6-(dimethylamino)-2-{[4-(naphthalene-2-amido)phenyl]methyl}pyrimidin-5-yl]acetic acid

Smiles: CN(C)C1=NC(CC2C=CC(=CC=2)NC(=O)C2=CC3=CC=CC=C3C=C2)=NC(Cl)=C1CC(O)=O

InChiKey: CUNNBJJEJUDKNN-UHFFFAOYSA-N

InChi: InChI=1S/C26H23ClN4O3/c1-31(2)25-21(15-23(32)33)24(27)29-22(30-25)13-16-7-11-20(12-8-16)28-26(34)19-10-9-17-5-3-4-6-18(17)14-19/h3-12,14H,13,15H2,1-2H3,(H,28,34)(H,32,33)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) protein, also known as GPR44, is a G-protein coupled receptor (GPCR) which is amongst other ligands most strongly activated by prostaglandin D2 (PGD2). PGD2 is a product of prostaglandin D2 synthase (PTGDS).

Products are for research use only. Not for human use.