Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.

Product information

Molecular Weight: 502.30

Formula: C19H23IN2O6

Chemical Name: 3-[6-[2-[2-(2-iodoethoxy)ethoxy]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2, 6-dione

Smiles: O=C1CCC(C(=O)N1)N1CC2=CC(=CC=C2C1=O)OCCOCCOCCI

InChiKey: OTGXRHVQVDOJKI-UHFFFAOYSA-N

InChi: InChI=1S/C19H23IN2O6/c20-5-6-26-7-8-27-9-10-28-14-1-2-15-13(11-14)12-22(19(15)25)16-3-4-17(23)21-18(16)24/h1-2,11,16H,3-10,12H2,(H,21,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Lenalidomide is a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). SJF620 is a potent PROTAC BTK degrader consisting of the BTK inhibitor conjugated to Lenalidomide by a linker.

Products are for research use only. Not for human use.