F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress.

Product information

CAS Number: 208109-39-1

Molecular Weight: 538.97

Formula: C25H29ClF2N4O5

Chemical Name: (2E)-but-2-enedioic acid; 6-[({[1-(3-chloro-4-fluorobenzoyl)-4-fluoropiperidin-4-yl]methyl}amino)methyl]-N,3-dimethylpyridin-2-amine

Smiles: CC1=CC=C(CNCC2(F)CCN(CC2)C(=O)C2=CC=C(F)C(Cl)=C2)N=C1NC.OC(=O)/C=C/C(O)=O

InChiKey: HZJWIYFEDQNBEU-WLHGVMLRSA-N

InChi: InChI=1S/C21H25ClF2N4O.C4H4O4/c1-14-3-5-16(27-19(14)25-2)12-26-13-21(24)7-9-28(10-8-21)20(29)15-4-6-18(23)17(22)11-15;5-3(6)1-2-4(7)8/h3-6,11,26H,7-10,12-13H2,1-2H3,(H,25,27);1-2H,(H,5,6)(H,7,8)/b;2-1+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (463.85 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

F13714 targets 5-HT1A autoreceptors.

In Vivo:

In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels. F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%. F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in naïve rats.

Products are for research use only. Not for human use.