MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells.

Product information

CAS Number: 863115-70-2

Molecular Weight: 424.42

Formula: C23H21FN2O5

Chemical Name: N-{1-[(2H-1,3-benzodioxol-5-yl)methyl]piperidin-4-yl}-6-fluoro-4-oxo-4H-chromene-2-carboxamide

Smiles: O=C1C=C(OC2=CC=C(F)C=C12)C(=O)NC1CCN(CC2C=C3OCOC3=CC=2)CC1

InChiKey: HHCYCBKPWYJVEB-UHFFFAOYSA-N

InChi: InChI=1S/C23H21FN2O5/c24-15-2-4-19-17(10-15)18(27)11-22(31-19)23(28)25-16-5-7-26(8-6-16)12-14-1-3-20-21(9-14)30-13-29-20/h1-4,9-11,16H,5-8,12-13H2,(H,25,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 10 mg/mL (23.56 mM; ultrasonic and adjust pH to 6 with HCl).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

MCHR1 antagonist 2 (Compound 30) is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM. MCHR1 antagonist 2 has inhibitory effects on Ca2+ flux, and hERG, with IC50s of 196 ± 30 nM and 4.0 ± 0.8 nM, respectively, in IMR-32 cells.

Products are for research use only. Not for human use.