CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer.

Product information

CAS Number: 258326-83-9

Molecular Weight: 723.75

Formula: C36H46N5O9P

Chemical Name: ({4-[(2S)-2-[(1-{[(1S)-2-carbamoyl-1-{[3-(2-hydroxynaphthalen-1-yl)propyl]carbamoyl}ethyl]carbamoyl}cyclohexyl)carbamoyl]-2-acetamidoethyl]phenyl}methyl)phosphonic acid

Smiles: CC(=O)N[C@@H](CC1=CC=C(CP(O)(O)=O)C=C1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1C2C=CC=CC=2C=CC=1O

InChiKey: DXUDLEHAROCUHM-KYJUHHDHSA-N

InChi: InChI=1S/C36H46N5O9P/c1-23(42)39-29(20-24-11-13-25(14-12-24)22-51(48,49)50)34(46)41-36(17-5-2-6-18-36)35(47)40-30(21-32(37)44)33(45)38-19-7-10-28-27-9-4-3-8-26(27)15-16-31(28)43/h3-4,8-9,11-16,29-30,43H,2,5-7,10,17-22H2,1H3,(H2,37,44)(H,38,45)(H,39,42)(H,40,47)(H,41,46)(H2,48,49,50)/t29-,30-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (345.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CGP78850 (0~100 μM; 90 minutes; MDA-MB-468 cells) reduces the amount of associated Grb2 protein in a dose-dependent manner. CGP78850 blocks epidermal growth factor receptor (EGFR)-Grb2 and Shc-Grb2 interaction in living cells. CGP78850 inhibits MDA-MB-468 cells to form colonies in soft agar in a dose-dependent manner.

Products are for research use only. Not for human use.