KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity.

Product information

CAS Number: 2138882-71-8

Molecular Weight: 335.16

Formula: C15H9Cl2FN4

Chemical Name: 4,6-dichloro-N-{4'-fluoro-[1,1'-biphenyl]-4-yl}-1,3,5-triazin-2-amine

Smiles: FC1C=CC(=CC=1)C1C=CC(=CC=1)NC1N=C(Cl)N=C(Cl)N=1

InChiKey: DUROVTLUQOYUPH-UHFFFAOYSA-N

InChi: InChI=1S/C15H9Cl2FN4/c16-13-20-14(17)22-15(21-13)19-12-7-3-10(4-8-12)9-1-5-11(18)6-2-9/h1-8H,(H,19,20,21,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (298.36 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

KEA1-97 (100 μM; 231MFP cells) impaires thioredoxin pulldown of caspase 3. KEA1-97 (10 μM; 48 hours; 231MFP cells) impaires 231MFP serum-free cell proliferation. KEA1-97 (10 μM; 0~12 hours; 231MFP cells) activates caspase 3/7 and induces apoptotic cell death. KEA1-97 (231MFP cells) resistants to survival and proliferation impairments.

In Vivo:

KEA1-97 (5 mg/kg; i.p.; 50 days) attenuates tumor xenograft growth.

Products are for research use only. Not for human use.