ABCAC rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES9418-50, ES9418-100

Citations, Manuals and MSDS Available upon request.

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],

Source: Rabbit

Applications: IHC; IF

Dilution: IHC-p 1:50-300

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from human protein . at AA range: 2170-2250

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 285kD

Human Gene ID: 26154

Human SWISS Prot NO: Q86UK0

Subcellular Location: Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Golgi apparatus membrane. Localizes in the limiting membrane of the lamellar granules (LGs) (PubMed:17927575). Trafficks from the Golgi apparatus to the lamellar granules (LGs) at the cell periphery in the uppermost granular layer keratinocytes where ABCA12-positive LGs fuse with the keratinocyte-cell membrane to secrete their lipid content to the extracellular space of the stratum corneum (PubMed:16007253, PubMed:17927575). Co-localizes through the Golgi apparatus to the cell periphery with glucosylceramide (PubMed:17927575).

Research Use Only