Cefsulodin sodium salt hydrate is a third generation β lactam antibiotic and member of the cephems subgroub of antibiotics. Target: Antibacterial The compound displays a mechanism of action like many β lactam antibiotics through inhibition of cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) crosslinking of peptidoglycan resulting in inhibition of the final transpeptidation step. Through the inability for Cefsulodin sodium salt hydrate to inhibit cefsulodin-resistant mutants of Pseudomonas aeruginosa PAO4089 growth displayed that Cefsulodin sodium salt hydrate may compete with PBP3 in addtion to PBP1A and PBP1B.

Product information

CAS Number: 52152-93-9

Molecular Weight: 554.53

Formula: C22H19N4NaO8S2

Chemical Name: 4-carbamoyl-1-{[(6R,7R)-2-carboxylato-6-hydrogenio-8-oxo-7-[(2R)-2-phenyl-2-[(sodiooxy)sulfonyl]acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}pyridin-1-ium

Smiles: NC(=O)C1C=C[N+](CC2CS[C@@H]3[C@H](NC(=O)[C@@H](C4C=CC=CC=4)S(=O)(=O)O[Na])C(=O)N3C=2C([O-])=O)=CC=1

InChiKey: REACMANCWHKJSM-DWBVFMGKSA-M

InChi: InChI=1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 13.5 mg/mL (24.34 mM; Need ultrasonic). H2O : 55 mg/mL (99.18 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. King A, et al. In vitro antibacterial activity and susceptibility of cefsulodin, an antipseudomonal cephalosporin, to beta-lactamases. Antimicrob Agents Chemother. 1980 Feb;17(2):165-9.
2. Gotoh N, et al. Resistance of Pseudomonas aeruginosa to cefsulodin: modification of penicillin-binding protein 3 and mapping of its chromosomal gene. J Antimicrob Chemother. 1990 Apr;25(4):513-23.
3. Alonso JL, et al. Differential susceptibility of aeromonads and coliforms to cefsulodin. Appl Environ Microbiol. 1996 Jun;62(6):1885-8.

Products are for research use only. Not for human use.