Methyltetrazine-amido-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 2322322-23-4

Molecular Weight: 487.55

Formula: C24H33N5O6

Chemical Name: N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}-4,7,10,13,16-pentaoxanonadec-18-ynamide

Smiles: CC1=NN=C(N=N1)C1=CC=C(CNC(=O)CCOCCOCCOCCOCCOCC#C)C=C1

InChiKey: OHZFOEAHYKQSRL-UHFFFAOYSA-N

InChi: InChI=1S/C24H33N5O6/c1-3-9-31-11-13-33-15-17-35-18-16-34-14-12-32-10-8-23(30)25-19-21-4-6-22(7-5-21)24-28-26-20(2)27-29-24/h1,4-7H,8-19H2,2H3,(H,25,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.